Article
The effect of rabbit anti-thymocyte globulin induction therapy on regulatory T cells in kidney transplant patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 May 2009
Sewgobind Varsha D K D, Kho Marcia M L, van der Laan Luc J W, Hendrikx Thijs K, van Dam Thea, Tilanus Hugo W, IJzermans Jan N M, Weimar Willem, Baan Carla C
Abstract excerpt
BACKGROUND: Prevention of alloreactivity by rabbit anti-thymocyte globulins (rATG) may not only result from immunodepletion but also from the induction of T cells that control allogeneic immune responses. In the present prospective and controlled study, we investigated the effect of rATG on the frequency, function and phenotype of peripheral immunoregulatory CD4+ T cells in kidney transplant (KTx) patients....
Topics
- Adult
- Aged
- Animals
- Antilymphocyte Serum
- Cell Count
- Coculture Techniques
- Drug Therapy, Combination
- Female
- Forkhead Transcription Factors
- Graft Rejection
- Humans
- Immunosuppressive Agents