Article
Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype.
Haematologica - 1 Apr 2005
Maccario Rita, Podestà Marina, Moretta Antonia, Cometa Angela, Comoli Patrizia, Montagna Daniela, Daudt Liane, Ibatici Adalberto, Piaggio Giovanna, Pozzi Sarah, Frassoni Francesco, Locatelli Franco
Abstract excerpt
BACKGROUND AND OBJECTIVES: Experimental evidence and preliminary clinical studies have demonstrated that human mesenchymal stem cells (MSC) have an important immune modulatory function in the setting of allogeneic hematopoietic stem cell (HSC) transplantation. We extended the evaluation of mechanisms responsible for the immune regulatory effect derived from the interaction of human MSC with cells involved in...
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