Article
Glutathione transferase P1-1 expression in human melanoma metastases: correlation to N-RAS mutations and expression.
Acta oncologica (Stockholm, Sweden) - 1 Jan 1995
Platz A, Jungnelius U, Grafström E, Lagerlöf B, Mannervik B, Ringborg U
Abstract excerpt
Expression of the detoxication enzyme glutathione transferase P1-1 (GST P1-1) at elevated levels has been noted in many types of human tumors, including melanomas. The products of the human H-RAS, K-RAS and N-RAS genes play a key role in intracellular signal transduction leading to transcriptiona...
Topics
- Biomarkers, Tumor
- Codon
- Female
- Fluorescent Antibody Technique
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Genes, fos
- Genes, jun
- Genes, ras
- Glutathione Transferase
- Humans
- Male
- Melanoma
- Mutation
- Signal Transduction
- Skin Neoplasms
- Transcription, Genetic