Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutathione transferase P1-1 expression in human melanoma metastases: correlation to N-RAS mutations and expression.

Acta oncologica (Stockholm, Sweden) - 1 Jan 1995

Platz A, Jungnelius U, Grafström E, Lagerlöf B, Mannervik B, Ringborg U

Abstract excerpt

Expression of the detoxication enzyme glutathione transferase P1-1 (GST P1-1) at elevated levels has been noted in many types of human tumors, including melanomas. The products of the human H-RAS, K-RAS and N-RAS genes play a key role in intracellular signal transduction leading to transcriptional activation of AP-1 (Fos/Jun) responsive genes. The oncogenic mutated forms of the ras proteins are constitutively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon
Share to Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Gene Expression Regulation, Neoplastic

Share to Genes, ras

Share to Mutation

Share to Signal Transduction

Share to Transcription, Genetic

Source

Identifiers

PMID: 7576742
DOI: 10.3109/02841869509127183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Glutathione transferase P1-1 expression in human melanoma metastases: correlation to N-RAS mutations and expression.PMID 7576742Read ↗

Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: mutations occur early and persist throughout tumor progression.Semantic proximity Read ↗

Ras mutations in human melanoma: a marker of malignant progression.Semantic proximity Read ↗

N-ras oncogene expression changes the growth characteristics of human melanoma in two independent SCID-hu mouse models.Semantic proximity Read ↗

Mutations and defective expression of the WAF1 p21 tumour-suppressor gene in malignant melanomas.Semantic proximity Read ↗

Melanoma metastases from patients with hereditary cutaneous malignant melanoma contain a high frequency of N-ras activating mutations.Semantic proximity Read ↗

RB1 oncosuppressor gene over-expression inhibits tumor progression and induces melanogenesis in metastatic melanoma cells.Semantic proximity Read ↗

Glutathione S-transferase GSTM1 null genotype is not overrepresented in Australian patients with nevoid basal cell carcinoma syndrome or sporadic melanoma.Semantic proximity Read ↗

Combined effects of GSTP1 and MRP1 in melanoma drug resistanceSemantic proximity Read ↗

Expression of the wt1 Wilms' tumor gene by normal and malignant human melanocytes.Semantic proximity Read ↗

Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.