Article
RB1 oncosuppressor gene over-expression inhibits tumor progression and induces melanogenesis in metastatic melanoma cells.
Oncogene - 19 Sept 1996
Valente P, Melchiori A, Paggi M G, Masiello L, Ribatti D, Santi L, Takahashi R, Albini A, Noonan D M
Abstract excerpt
The retinoblastoma gene (RB1) is frequently deleted or mutated in many tumor types and in all cases of retinoblastoma. Apart from its role in regulation of the cell cycle, the RB1 gene product (p110RB1) appears to be involved in control of differentiation. Malignant metastatic cells show many pro...
Topics
- Animals
- Cell Division
- Cell Movement
- Culture Media
- DNA, Complementary
- Disease Progression
- Gene Expression
- Genes, Retinoblastoma
- Humans
- Melanins
- Melanoma, Experimental
- Mice
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neovascularization, Pathologic
- Phenotype
- Retinoblastoma Protein
- Transfection