Article
RB1 oncosuppressor gene over-expression inhibits tumor progression and induces melanogenesis in metastatic melanoma cells.
Oncogene - 19 Sept 1996
Valente P, Melchiori A, Paggi M G, Masiello L, Ribatti D, Santi L, Takahashi R, Albini A, Noonan D M
Abstract excerpt
The retinoblastoma gene (RB1) is frequently deleted or mutated in many tumor types and in all cases of retinoblastoma. Apart from its role in regulation of the cell cycle, the RB1 gene product (p110RB1) appears to be involved in control of differentiation. Malignant metastatic cells show many properties of poorly differentiated cells, and are highly invasive in vitro and in vivo. We have transfected the human RB1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.