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Article

Combined effects of GSTP1 and MRP1 in melanoma drug resistance

1 Jul 2005

Abstract excerpt

Glutathione-S-transferase Pi1 (GSTP1) and multidrug resistance protein 1 (MRP1) are overexpressed in melanoma, a skin cancer notoriously resistant to all current modalities of cancer therapy. To investigate the involvement of these detoxifying enzymes in the drug resistance of melanoma, an inducible (Tet-On system) antisense (AS) RNA strategy was used to specifically inhibit GSTP1 expression in A375 cells, a...

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PMID: 15999103
DOI: 10.1038/sj.bjc.6602681

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