Article
Expression of the wt1 Wilms' tumor gene by normal and malignant human melanocytes.
International journal of cancer - 1 Oct 1994
Rodeck U, Bossler A, Kari C, Humphreys C W, Györfi T, Maurer J, Thiel E, Menssen H D
Abstract excerpt
We report expression of the wt1 (Wilms' tumor) gene by cultured human melanoma cells. Using RNA polymerase chain reaction analysis, wt1 transcripts were detected in 7 of 9 melanoma cell lines but not in 5 normal melanocyte strains. In Northern blot analysis, steady-state wt1 mRNA levels were foun...
Topics
- Base Sequence
- Blotting, Northern
- DNA, Complementary
- Gene Expression
- Genes, Wilms Tumor
- Genes, p53
- Humans
- Melanocytes
- Melanoma
- Molecular Sequence Data
- Mutation
- Platelet-Derived Growth Factor
- Polymerase Chain Reaction
- RNA Splicing
- RNA, Messenger
- Tumor Cells, Cultured