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Article

Evolution of broad host range in retroviruses leads to cell death mediated by highly cytopathic variants.

Journal of virology - 1 Jan 2006

Rainey G Jonah A, Coffin John M

Abstract excerpt

The ability of many retroviruses to cause disease can be correlated to their cytopathic effect (CPE) in tissue culture characterized by an acute period of cell death and viral DNA accumulation. Here, we show that mutants of a subgroup B avian retrovirus (Alpharetrovirus) cause a very dramatic CPE in certain susceptible avian cells that is coincident with elevated levels of apoptosis, as measured by nuclear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16378958
DOI: 10.1128/JVI.80.2.562-570.2006
PMCID: PMC1346834

Genes

CPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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