Article
Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants.
Virology - 30 Sept 2010
Mishima Kako, Sakamoto Naoya, Sekine-Osajima Yuko, Nakagawa Mina, Itsui Yasuhiro, Azuma Seishin, Kakinuma Sei, Kiyohashi Kei, Kitazume Akiko, Tsuchiya Kiichiro, Imamura Michio, Hiraga Nobuhiko, Chayama Kazuaki, Wakita Takaji, Watanabe Mamoru
Abstract excerpt
HCV-JFH1 yields subclones that develop cytopathic plaques (Sekine-Osajima Y, et al., Virology 2008; 371:71). Here, we investigated viral amino acid substitutions in cytopathic mutant HCV-JFH1 clones and their characteristics in vitro and in vivo. The mutant viruses with individual C2441S, P2938S or R2985P signature substitutions, and with all three substitutions, showed significantly higher intracellular...
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