Article
An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell.
Development (Cambridge, England) - 1 Jun 1996
Mickey K M, Mello C C, Montgomery M K, Fire A, Priess J R
Abstract excerpt
During the 4-cell stage of C. elegans embryogenesis, the P2 blastomere provides a signal that allows two initially equivalent sister blastomeres, called ABa and ABp, to adopt different fates. Preventing P2 signalling in wild-type embryos results in defects in ABp development that are similar to those caused by mutations in the glp-1 and apx-1 genes, which are homologs of the Drosophila genes Notch and Delta,...
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