Article
Protein evolution on partially correlated landscapes.
Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 1995
Perelson A S, Macken C A
Abstract excerpt
We extend an earlier model of protein evolution on a rugged landscape to the case in which the landscape exhibits a variable degree of correlation (i.e., smoothness). Correlation is introduced by assuming that a protein is composed of a set of independent blocks or domains and that mutation in one block affects the contribution of that block alone to the overall fitness of the protein. We study the statistical...
Topics
- Adaptation, Biological
- Antibodies
- Biological Evolution
- Models, Genetic
- Mutation
- Protein Conformation
- Proteins
- Selection, Genetic