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Article

Inference of annealed protein fitness landscapes with AnnealDCA.

PLoS computational biology - 1 Feb 2024

Sesta Luca, Pagnani Andrea, Fernandez-de-Cossio-Diaz Jorge, Uguzzoni Guido

Abstract excerpt

The design of proteins with specific tasks is a major challenge in molecular biology with important diagnostic and therapeutic applications. High-throughput screening methods have been developed to systematically evaluate protein activity, but only a small fraction of possible protein variants can be tested using these techniques. Computational models that explore the sequence space in-silico to identify the...

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PMID: 38377054
DOI: 10.1371/journal.pcbi.1011812
PMCID: PMC10878520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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