p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China.

Abstract excerpt

DNA samples from 36 hepatocellular carcinoma (HCC) patients from China were screened for a specific mutation affecting codon 249 of the p53 gene, recently identified as a hotspot mutation in some HCCs. We detected the tumor-specific p53 codon 249 mutation in 21 (58%) of 36 HCCs examined. Thirteen patients with the specific codon 249 mutation had lost the remaining allele of p53, whereas the remaining eight...

Topics

• Adult
• Carcinoma, Hepatocellular
• China
• Chromosome Deletion
• Chromosomes, Human, Pair 17
• Codon
• Female
• Genes, p53
• Hepatitis B virus
• Humans
• Liver Neoplasms
• Male