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Article

P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.

Head & neck - 1 Aug 2003

Bradford Carol R, Zhu Shaobo, Ogawa Haruko, Ogawa Tetsuya, Ubell Matthew, Narayan Ajita, Johnson Garfield, Wolf Gregory T, Fisher Susan G, Carey Thomas E

Abstract excerpt

BACKGROUND: A critical factor for successful organ preservation treatment in head and neck cancer may be selecting tumors that respond to chemotherapy and radiation. Previous results in patients indicated that tumors that overexpressed p53 were more sensitive to chemotherapy than those that did not overexpress p53. METHODS: To determine the relationship of p53 mutations to sensitivity to cisplatin in vitro, 23...

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Share to Antineoplastic Agents
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cisplatin

Share to Dose-Response Relationship, Drug

Share to Drug Resistance, Neoplasm

Share to Genes, p53

Share to Head and Neck Neoplasms

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12884349
DOI: 10.1002/hed.10274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.PMID 12884349Read ↗

Reduced cisplatin sensitivity of head and neck squamous cell carcinoma cell lines correlates with mutations affecting the COOH-terminal nuclear localization signal of p53.Semantic proximity Read ↗

DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.Semantic proximity Read ↗

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Mutation of p53 in head and neck squamous cell carcinoma correlates with Bcl-2 expression and increased susceptibility to cisplatin-induced apoptosis.Semantic proximity Read ↗

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