Article
Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization.
Nature - 12 Oct 1995
Erdélyi M, Michon A M, Guichet A, Glotzer J B, Ephrussi A
Abstract excerpt
The localization of oskar (osk) RNA to the posterior pole of the developing fruit fly (Drosophila) oocyte induces the assembly of pole plasm, causing development of the abdomen and germ line. Failure to localize oskar RNA results in embryos that lack abdomen and germ cells. Conversely, mis-targeting of oskar RNA to the anterior of the oocyte causes formation of ectopic abdomen and germ cells at the anterior pole....
Topics
- Actins
- Animals
- Cell Polarity
- Cytoplasm
- Drosophila
- Drosophila Proteins
- Female
- Mutation
- Oocytes
- Proteins
- RNA, Messenger
- RNA-Binding Proteins