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Article

poirot, a new regulatory gene of Drosophila oskar acts at the level of the short Oskar protein isoform.

Development (Cambridge, England) - 1 Jul 2002

Sinka Rita, Jankovics Ferenc, Somogyi Kálmán, Szlanka Tamás, Lukácsovich Tamás, Erdélyi Miklós

Abstract excerpt

Embryonic germ cell formation and abdomen development in Drosophila requires localisation and site specific translation of oskar mRNA in the posterior part of the oocyte. Targeting of oskar function to the posterior pole of the oocyte needs a large set of proteins and RNAs, encoded by posterior group genes. Consequently, mutations in the posterior group genes can result in embryos without abdomens and/or germ...

Topics

Amino Acid Sequence
Animals
Animals, Genetically Modified
Base Sequence
DNA
Drosophila Proteins
Drosophila melanogaster
Female
Gene Expression Regulation, Developmental
Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Regulator

Molecular Sequence Data

Mutation

Oocytes

Oogenesis

Protein Isoforms

RNA Splicing

RNA, Messenger

Source

Identifiers

PMID: 12091316
DOI: 10.1242/dev.129.14.3469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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poirot, a new regulatory gene of Drosophila oskar acts at the level of the short Oskar protein isoform.PMID 12091316Read ↗

oskar mRNA is localized to the posterior pole of the Drosophila oocyte.Semantic proximity Read ↗

A late phase of Oskar accumulation is crucial for posterior patterning of the Drosophila embryo, and is blocked by ectopic expression of Bruno.Semantic proximity Read ↗

oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction.Semantic proximity Read ↗

A late phase of germ plasm accumulation during Drosophila oogenesis requires lost and rumpelstiltskin.Semantic proximity Read ↗

Oskar organizes the germ plasm and directs localization of the posterior determinant nanos.Semantic proximity Read ↗

Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole.Semantic proximity Read ↗

Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation.Semantic proximity Read ↗

Two distinct domains of Bruno bind specifically to the oskar mRNA.Semantic proximity Read ↗

The endocytic pathway acts downstream of Oskar in Drosophila germ plasm assembly.Semantic proximity Read ↗

Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential.Semantic proximity Read ↗

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation.Semantic proximity Read ↗

Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport.Semantic proximity Read ↗

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