Article
Spontaneous malignant transformation of melanocytes explanted from Wf/Wf mice with a Kit kinase-domain mutation.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1992
Larue L, Dougherty N, Porter S, Mintz B
Abstract excerpt
The W/Kit mouse locus, affecting proliferation and survival of pigment cells, blood cells, and germ cells, is known to encode a tyrosine kinase growth factor receptor and is considered a protooncogene; yet it has not heretofore been causally implicated in any malignancies of those cells. The Wf/W...
Topics
- Animals
- Base Sequence
- Cell Death
- Cell Line
- Cell Transformation, Neoplastic
- Cells, Cultured
- Genes, Dominant
- Genotype
- Melanocytes
- Melanoma, Experimental
- Mice
- Mice, Inbred C3H
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins