Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes.

doi:10.1016/s0140-6736(95)92709-3

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Article

Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes.

Lancet (London, England) - 30 Sept 1995

Ruiz J, Blanché H, James R W, Garin M C, Vaisse C, Charpentier G, Cohen N, Morabia A, Passa P, Froguel P

Abstract excerpt

Paraoxonase is a high-density-lipoprotein-associated enzyme capable of hydrolysing lipid peroxides. Thus it might protect lipoproteins from oxidation. It has two isoforms, which arise from a glutamine (A isoform) to arginine (B isoform) interchange at position 192. The relevance of this polymorph...

Topics

Arginine
Aryldialkylphosphatase
Case-Control Studies
Coronary Disease
Diabetes Mellitus, Type 2
Esterases
Female
Genotype
Glutamine
Humans
Male
Middle Aged
Polymorphism, Genetic
Regression Analysis
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 7564671
DOI: 10.1016/s0140-6736(95)92709-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7564671-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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