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Article

Paraoxonase 1 192 Gln/Arg gene polymorphism and cerebrovascular disease: interaction with type 2 diabetes.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Jan 2001

Koch M, Hering S, Barth C, Ehren M, Enderle M D, Pfohl M

Abstract excerpt

Paraoxonase 1 (PON1) is an HDL-associated enzyme which protects HDL and LDL particles from lipid peroxidation. Its enzymatic serum activity varies 10-40-fold between individuals, and its biallelic gene polymorphism at codon 192 (glutamine-->arginine, Gln/Arg) has been associated with coronary art...

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Source

Identifiers

PMID: 11409295
DOI: 10.1055/s-2001-14836

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11409295-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Paraoxonase 1 192 Gln/Arg gene polymorphism and cerebrovascular disease: interaction with type 2 diabetes.PMID 11409295Read ↗

Paraoxonase 192 Gln/Arg gene polymorphism, coronary artery disease, and myocardial infarction in type 2 diabetes.Semantic proximity Read ↗

The influence of PON1 192 polymorphism on endothelial function in diabetic subjects with or without hypertension.Semantic proximity Read ↗

Gln-Arg192 polymorphism of paraoxonase 1 is associated with carotid intima-media thickness in patients of type 2 diabetes mellitus of Chinese.Semantic proximity Read ↗

Risk of myocardial infarction associated with Gln/Arg 192 polymorphism in the human paraoxonase gene and diabetes mellitus. The REGICOR Investigators.Semantic proximity Read ↗

Paraoxonase 192 Gln-->Arg polymorphism: an independent risk factor for nonfatal arterial ischemic stroke among young adults.Semantic proximity Read ↗

Paraoxonase 1 Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus.Semantic proximity Read ↗

The gln-Arg192 polymorphism of human paraoxonase gene is not associated with coronary artery disease in italian patients.Semantic proximity Read ↗

Influence of the human paraoxonase polymorphism (PON1 192) on the carotid-wall thickening in a healthy population.Semantic proximity Read ↗

The Arg allele in position 192 of PON1 is associated with carotid atherosclerosis in subjects with elevated HDLs.Semantic proximity Read ↗

The paraoxonase Gln-Arg 192 polymorphism in subjects with ischaemic heart disease.Semantic proximity Read ↗

Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes.Semantic proximity Read ↗

Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype.Semantic proximity Read ↗

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