Article
GABA receptor minigene rescues insecticide resistance phenotypes in Drosophila.
Journal of molecular biology - 20 Oct 1995
Stilwell G E, Rocheleau T, ffrench-Constant R H
Abstract excerpt
A single point mutation within the GABA receptor gene Resistance to dieldrin (Rdl) confers a high level of resistance to cyclodiene insecticides in a wide range of insects. Previous studies have shown partial rescue of the susceptible phenotype via germline transformation of a 36 kb cosmid coding (or all four alternative Rdl splice forms. Here, we describe the construction of two Rdl promoter/cDNA minigenes, each...
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