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Article

A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated with cyclodiene insecticide resistance in Drosophila populations.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1993

ffrench-Constant R H, Steichen J C, Rocheleau T A, Aronstein K, Roush R T

Abstract excerpt

Resistance to cyclodiene insecticides, documented in at least 277 species, is perhaps the most common kind of resistance to any pesticide. By using cyclodiene resistance to localize the responsible gene, a gamma-aminobutyric acid type A receptor/chloride ion-channel gene was previously cloned and sequenced from an insecticide-susceptible Drosophila melanogaster strain. We now describe the molecular genetics of...

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Identifiers

PMID: 8095336
DOI: 10.1073/pnas.90.5.1957
PMCID: PMC45999

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