Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus.

doi:10.1073/pnas.88.16.7209

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Article

Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1991

Ffrench-Constant R H, Mortlock D P, Shaffer C D, MacIntyre R J, Roush R T

Abstract excerpt

Cyclodiene resistance represents 60% of the reported cases of insecticide resistance and is also present in vertebrates. Resistance is due to insensitivity of the cyclodiene/picrotoxinin binding site on the gamma-aminobutyric acid subtype A (GABAA) receptor-chloride ionophore complex. Following isolation of cyclodiene-resistant Drosophila mutants, we report the cloning of the locus conferring resistance via a...

Topics

Amino Acid Sequence
Animals
Cattle
Chromosome Walking
Cloning, Molecular
Cosmids
Crosses, Genetic
DNA
DNA Transposable Elements
Dieldrin
Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance

Female

Gene Rearrangement

Insecticides

Macromolecular Substances

Male

Molecular Sequence Data

Source

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Identifiers

PMID: 1651498
DOI: 10.1073/pnas.88.16.7209
PMCID: PMC52263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1651498-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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