Article
A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms.
The Journal of physiology - 15 Aug 1994
Zhang H G, ffrench-Constant R H, Jackson M B
Abstract excerpt
1. The Drosophila gene Rdl (resistance to dieldrin) encodes a GABA receptor. An alanine-to-serine mutation in this gene at residue 302 confers resistance to cyclodiene insecticides and picrotoxin. Patch clamp analysis of GABA receptors in cultured neurons from wild type and mutant Drosophila was undertaken to investigate the biophysical basis of resistance. 2. In cultured neurons from both wild type and mutant...
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