A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms.

doi:10.1113/jphysiol.1994.sp020278

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Article

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms.

The Journal of physiology - 15 Aug 1994

Zhang H G, ffrench-Constant R H, Jackson M B

Abstract excerpt

1. The Drosophila gene Rdl (resistance to dieldrin) encodes a GABA receptor. An alanine-to-serine mutation in this gene at residue 302 confers resistance to cyclodiene insecticides and picrotoxin. Patch clamp analysis of GABA receptors in cultured neurons from wild type and mutant Drosophila was...

Topics

Alanine
Animals
Binding Sites
Cells, Cultured
Dieldrin
Dose-Response Relationship, Drug
Drosophila
Hexachlorocyclohexane
Insecticide Resistance
Insecticides
Mutation
Neurons
Picrotoxin
Receptors, GABA
Serine

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