Article
In vitro evaluation of B-CLL cells apoptotic responses to irradiation.
Leukemia & lymphoma - 1 Jun 1999
Comby E, Andre I, Troussard X, Lebrun E, Sola B, Ballet J J, Leporrier M
Abstract excerpt
Defective apoptosis is a mechanism which could possibly explain B chronic lymphocytic leukemia (B-CLL) cell accumulation. Differences in evolution and prognosis of B-CLL patients may be due to heterogeneity in apoptotic cell death. We studied the apoptotic response to in vitro gamma radiation of blood mononuclear cells from 18 untreated B-CLL patients. In cells irradiated with 2, 4 or 8 Gy and then cultured for...
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