Article
Identification of a gene encoding a yeast histone H4 acetyltransferase.
The Journal of biological chemistry - 20 Oct 1995
Kleff S, Andrulis E D, Anderson C W, Sternglanz R
Abstract excerpt
A collection of yeast temperature-sensitive mutants was screened by an enzymatic assay to find a mutant defective in the acetylation of histone H4. The assay used a fractionated cell extract and measured acetylation of a peptide corresponding to amino acids 1-28 of H4. There are at least two activities in this fraction that acetylate the peptide. A mutation, hat1-1, that eliminates one of the activities was...
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