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Article

Involvement of Hat1p (Kat1p) catalytic activity and subcellular localization in telomeric silencing.

The Journal of biological chemistry - 24 Oct 2008

Mersfelder Erica L, Parthun Mark R

Abstract excerpt

Previous studies have shown that loss of the type B histone acetyltransferase Hat1p leads to defects in telomeric silencing in Saccharomyces cerevisiae. We used this phenotype to explore a number of functional characteristics of this enzyme. To determine whether the enzymatic activity of Hat1p is necessary for its role in telomeric silencing, a structurally conserved glutamic acid residue (Glu-255) that has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18753131
DOI: 10.1074/jbc.M802564200
PMCID: PMC2570870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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