Article
An Nalpha-acetyltransferase responsible for acetylation of the N-terminal residues of histones H4 and H2A.
The Journal of biological chemistry - 3 Oct 2003
Song Ok-kyu, Wang Xiaorong, Waterborg Jakob H, Sternglanz Rolf
Abstract excerpt
A yeast gene has been identified that encodes a novel, evolutionarily conserved Nalpha-acetyltransferase responsible for acetylation of the N-terminal residues of histones H4 and H2A. The gene has been named NAT4. Recombinant Nat4 protein acetylated a peptide corresponding to the N-terminal tail of H4, but not an H3 peptide nor the peptide adrenocorticotropin. H4 and H2A are N-terminally acetylated in all species...
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