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Article

Rapid allelic diversification and intensified selection at antigen recognition sites of the Mhc class II DPB1 locus during hominoid evolution.

Tissue antigens - 1 Mar 1996

Gyllensten U, Bergström T, Josefsson A, Sundvall M, Erlich H A

Abstract excerpt

The evolution of polymorphism at the Mhc class II DPB1 locus was studied by comparison of chimpanzee (Pan troglodytes), pygmy chimpanzee (Pan paniscus), gorilla (Gorilla gorilla) and human DPB1 alleles. Extensive polymorphism was found in all hominoids. The clustering of sequences in the phylogenetic tree is consistent with rapid generation of the DPB1 polymorphism. Analysis of the substitution pattern for human...

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PMID: 8740771
DOI: 10.1111/j.1399-0039.1996.tb02543.x

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