Article
Linkage analysis and allelic imbalance in human breast cancer kindreds using microsatellite markers from the short arm of chromosome 3.
Human genetics - 1 Oct 1995
Bergthorsson J T, Eiriksdottir G, Barkardottir R B, Egilsson V, Arason A, Ingvarsson S
Abstract excerpt
Eight Icelandic breast cancer kindreds were subjected to linkage analyses with respect to 28 microsatellite loci dispersed along the short arm of chromosome 3. Breast tumors derived from these kindreds were concurrently scored for allelic imbalance with ten of the markers. Linkage to most markers could be excluded on the basis of negative LOD scores and haplotype analyses, although some moderately positive LOD...
Topics
- Adult
- Alleles
- Breast Neoplasms
- Chromosomes, Human, Pair 3
- DNA, Neoplasm
- DNA, Satellite
- Female
- Genetic Linkage
- Humans
- Lod Score
- Middle Aged