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Article

Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3-3p21.3 in sporadic breast-cancer development.

International journal of cancer - 15 May 1994

Buchhagen D L, Qiu L, Etkind P

Abstract excerpt

DNAs from 19 malignant human breast tumors and 2 benign fibroadenomas were analyzed for heterozygosity at 5 polymorphic loci on the short arm of chromosome 3. One homozygous deletion and one rearrangement were identified using probe D3S2 which maps to 3p14.3-3p21.1. This probe also detected novel hybridizing fragments of 2.0 kb and/or 3.4 kb in 6/18 (33%) of the malignant tumor samples that hybridized with the...

Topics

Breast Neoplasms
Chromosome Aberrations
Chromosome Deletion
Chromosomes, Human, Pair 3
DNA Probes
DNA Restriction Enzymes
DNA, Neoplasm
Female
Fibroadenoma
Gene Amplification
Gene Rearrangement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Humans

Methylation

Nucleic Acid Hybridization

Polymerase Chain Reaction

Source

Identifiers

PMID: 8181852
DOI: 10.1002/ijc.2910570406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8181852-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3-3p21.3 in sporadic breast-cancer development.PMID 8181852Read ↗

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