Article
An activated mutant of the alpha subunit of G(o) increases neurite outgrowth via protein kinase C.
Brain research. Developmental brain research - 27 Jun 1995
Xie R, Li L, Goshima Y, Strittmatter S M
Abstract excerpt
The GTP-binding protein, G(o), is present at very high concentration in the neuronal growth cone membrane. The expression of activated mutants of the a subunit of G(o) increases neurite outgrowth. To determine the intracellular mechanism for this outgrowth, we have examined activated alpha o-dependent outgrowth in the presence of agents which modulate different signal transduction cascades. Activation of protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.