Article
An activated mutant of the alpha subunit of G(o) increases neurite outgrowth via protein kinase C.
Brain research. Developmental brain research - 27 Jun 1995
Xie R, Li L, Goshima Y, Strittmatter S M
Abstract excerpt
The GTP-binding protein, G(o), is present at very high concentration in the neuronal growth cone membrane. The expression of activated mutants of the a subunit of G(o) increases neurite outgrowth. To determine the intracellular mechanism for this outgrowth, we have examined activated alpha o-depe...
Topics
- Alkaloids
- Animals
- Calcium
- Calcium Channel Blockers
- Calcium-Transporting ATPases
- Dose-Response Relationship, Drug
- Enzyme Inhibitors
- Ethers, Cyclic
- GTP-Binding Proteins
- Gallic Acid
- Mutation
- Neurites
- Okadaic Acid
- PC12 Cells
- Protein Kinase C
- Rats
- Second Messenger Systems
- Staurosporine