Article
Modulation of the N-type calcium channel gene expression by the alpha subunit of Go.
Brain research. Molecular brain research - 10 Apr 2003
Kim Bum-Jun, Ghil Sung-Ho, Kim Min-Ji, Yun Park So, Kim Dong-Sun, Hwan Kim Sung, Chin Hemin, Birnbaumer Lutz, Jiang Meisheng, Hong Sung Youl, Suh-Kim Haeyoung, Lee Young-Don
Abstract excerpt
Go, a heterotrimeric G-protein, is enriched in brain and neuronal growth cones. Although several reports suggest that Go may be involved in modulation of neuronal differentiation, the precise role of Go is not clear. To investigate the function of Go in neuronal differentiation, we determined the effect of Goalpha, the alpha subunit of Go, on the expression of Ca(v)2.2, the pore-forming unit of N-type calcium...
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