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Survival and proliferative roles of erythropoietin beyond the erythroid lineage

1 Dec 2008

Abstract excerpt

Since the isolation and purification of erythropoietin (EPO) in 1977, the essential role of EPO for mature red blood cell production has been well established. The cloning of the EPO gene and production of recombinant human EPO led to the widespread use of EPO in treating patients with anaemia. However, the biological activity of EPO is not restricted to regulation of erythropoiesis. EPO receptor (EPOR)...

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PMID: 19040789
DOI: 10.1017/s1462399408000860

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