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Article

Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts

26 Jul 2013

Abstract excerpt

Primitive erythroid cells, the first red blood cells produced in the mammalian embryo, are necessary for embryonic survival. Erythropoietin and its receptor EpoR, are absolutely required for survival of late-stage definitive erythroid progenitors in the fetal liver and adult bone marrow. Epo- and Epor-null mice die at E13.5 with a lack of definitive erythrocytes. However, the persistence of circulating primitive...

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PMID: 23894012
DOI: 10.3324/haematol.2013.087361

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