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Article

Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells.

Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2005

Feldhahn Niklas, Río Paula, Soh Bonaventure Ndikung Bejeng, Liedtke Stefanie, Sprangers Mieke, Klein Florian, Wernet Peter, Jumaa Hassan, Hofmann Wolf-Karsten, Hanenberg Helmut, Rowley Janet D, Müschen Markus

Abstract excerpt

Bruton's tyrosine kinase (BTK) deficiency results in a differentiation block at the pre-B cell stage. Likewise, acute lymphoblastic leukemia cells are typically arrested at early stages of B cell development. We therefore investigated BTK function in B cell precursor leukemia cells carrying a BCR-ABL1, E2A-PBX1, MLL-AF4, TEL-AML1, or TEL-PDGFRB gene rearrangement. Although somatic mutations of the BTK gene are...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16141323
DOI: 10.1073/pnas.0505196102
PMCID: PMC1201599

Genes

BTK
ABL1
BCR
PBX1
PDGFRB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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