Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3.

Journal of molecular biology - 14 Jun 1996

Feng Y, Klein B K, McWherter C A

Abstract excerpt

The three-dimensional structure and backbone dynamics of a truncated and multiply substituted recombinant human interleukin-3 (IL-3) variant (SC-65369) have been determined from multidimensional heteronuclear nuclear magnetic resonance spectroscopic data. Sequential application of distance geometry and restrained molecular dynamics calculations produced a family of 25 convergent structures which satisfy a total...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Genetic Variation
Share to Magnetic Resonance Spectroscopy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Molecular Sequence Data

Share to Protein Conformation

Share to Protein Folding

Share to Recombinant Proteins

Source

Identifiers

PMID: 8676386
DOI: 10.1006/jmbi.1996.0337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3.PMID 8676386Read ↗

Deciphering the structural and functional impact of interleukin-3 (IL-3) variants: Insights from site-directed mutagenesis, computational modeling, molecular dynamics simulations, and implications for anticancer therapies and immune regulation.Semantic proximity Read ↗

Engineering and crystal structure of a monomeric FLT3 ligand variant.Semantic proximity Read ↗

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.Semantic proximity Read ↗

Conformational dynamics in loop swap mutants of homologous fibronectin type III domains.Semantic proximity Read ↗

NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer.Semantic proximity Read ↗

The DNA-binding domain of HIV-1 integrase has an SH3-like fold.Semantic proximity Read ↗

Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond.Semantic proximity Read ↗

Complete resonance assignment for the polypeptide backbone of interleukin 1 beta using three-dimensional heteronuclear NMR spectroscopy.Semantic proximity Read ↗

Solution conformation of wild-type and mutant IgG3 and IgG4 immunoglobulins using crystallohydrodynamics: possible implications for complement activation.Semantic proximity Read ↗

A novel dimer configuration revealed by the crystal structure at 2.4 Å resolution of human interleukin-5Semantic proximity Read ↗

Solution structure of human IL-13 and implication for receptor binding.Semantic proximity Read ↗

Comparison of solution structures of mutant bovine pancreatic trypsin inhibitor proteins using two-dimensional nuclear magnetic resonance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.