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Article

Analysis of K-ras gene mutations in malignant and nonmalignant endobronchial tissue obtained by fiberoptic bronchoscopy.

American journal of respiratory and critical care medicine - 1 Oct 1995

Clements N C, Nelson M A, Wymer J A, Savage C, Aguirre M, Garewal H

Abstract excerpt

Using polymerase chain reaction DNA amplification, we identified K-ras oncogene mutations in bronchial biopsies obtained from patients undergoing bronchoscopy for clinical indications. We hypothesized that these mutations would be found in a field encompassing malignant and nonmalignant tissues in patients with pulmonary carcinomas, and also possibly in tissue from some patients who smoked but did not have...

Topics

Aged
Biopsy
Bronchi
Bronchoscopy
Fiber Optic Technology
Genes, ras
Humans
Lung Neoplasms
Male
Mutation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single-Stranded Conformational

Smoking

Source

Identifiers

PMID: 7551397
DOI: 10.1164/ajrccm.152.4.7551397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7551397-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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