Article
Analysis of K-ras gene mutations in malignant and nonmalignant endobronchial tissue obtained by fiberoptic bronchoscopy.
American journal of respiratory and critical care medicine - 1 Oct 1995
Clements N C, Nelson M A, Wymer J A, Savage C, Aguirre M, Garewal H
Abstract excerpt
Using polymerase chain reaction DNA amplification, we identified K-ras oncogene mutations in bronchial biopsies obtained from patients undergoing bronchoscopy for clinical indications. We hypothesized that these mutations would be found in a field encompassing malignant and nonmalignant tissues in patients with pulmonary carcinomas, and also possibly in tissue from some patients who smoked but did not have...
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