Article
Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators.
Developmental biology - 1 Sept 1999
Nellesen D T, Lai E C, Posakony J W
Abstract excerpt
In Drosophila, genes of the Enhancer of split Complex [E(spl)-C] are important components of the Notch (N) cell-cell signaling pathway, which is utilized in imaginal discs to effect a series of cell fate decisions during adult peripheral nervous system development. Seven genes in the complex encode basic helix-loop-helix (bHLH) transcriptional repressors, while 4 others encode members of the Bearded family of...
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