Article
Enhancer of splitD, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1992
Tietze K, Oellers N, Knust E
Abstract excerpt
Helix-loop-helix proteins play important roles in developmental processes, such as myogenesis, neurogenesis, and sex determination. The gene Enhancer of split [E(spl)] of Drosophila, a member of a gene complex that is involved in early neurogenesis, encodes a protein with a basic domain and a hel...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA-Binding Proteins
- Drosophila melanogaster
- Genes
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Nervous System
- Oligodeoxyribonucleotides
- Restriction Mapping
- Structure-Activity Relationship