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Article

The origin of CD4-CD8-TCR alpha beta+ thymocytes: a model based on T-cell receptor avidity.

Immunology today - 1 Sept 1995

Budd R C, Mixter P F

Abstract excerpt

Ralph Budd and Philip Mixter present a hypothesis suggesting that CD4-CD8-TCR alpha beta+ cells arising in the normal thymus result from a high-avidity T-cell receptor (TCR) signal bordering on negative selection. In normal mice, this subset is likely to be gradually deleted but, in the absence of Fas, these cells persist in lpr mice. The model they describe makes several predictions regarding the nature of this...

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Source

Identifiers

PMID: 7546206
DOI: 10.1016/0167-5699(95)80019-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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