The origin of CD4-CD8-TCR alpha beta+ thymocytes: a model based on T-cell receptor avidity.

doi:10.1016/0167-5699(95)80019-0

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Article

The origin of CD4-CD8-TCR alpha beta+ thymocytes: a model based on T-cell receptor avidity.

Immunology today - 1 Sept 1995

Budd R C, Mixter P F

Abstract excerpt

Ralph Budd and Philip Mixter present a hypothesis suggesting that CD4-CD8-TCR alpha beta+ cells arising in the normal thymus result from a high-avidity T-cell receptor (TCR) signal bordering on negative selection. In normal mice, this subset is likely to be gradually deleted but, in the absence o...

Topics

Animals
CD4 Antigens
CD8 Antigens
Mice
Mice, Transgenic
Models, Biological
Phenotype
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocyte Subsets

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