Article
Diversity in intrinsic strengths of the human complement system: serum C4 protein concentrations correlate with C4 gene size and polygenic variations, hemolytic activities, and body mass index.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2003
Yang Yan, Chung Erwin K, Zhou Bi, Blanchong Carol A, Yu C Yung, Füst George, Kovács Margit, Vatay Agnes, Szalai Csaba, Karádi István, Varga Lilian
Abstract excerpt
Among the genes and proteins of the human immune system, complement component C4 is extraordinary in its frequent germline variation in the size and number of genes. Definitive genotypic and phenotypic analyses were performed on a central European population to determine the C4 polygenic and gene...
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