In vivo distribution and cytopathology of variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop.

doi:10.1128/JVI.68.9.5991-6005.1994

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

In vivo distribution and cytopathology of variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop.

Journal of virology - 1 Sept 1994

Donaldson Y K, Bell J E, Holmes E C, Hughes E S, Brown H K, Simmonds P

Abstract excerpt

The distribution, cell tropism, and cytopathology in vivo of human immunodeficiency virus (HIV) was investigated in postmortem tissue samples from a series of HIV-infected individuals who died either of complications associated with AIDS or for unrelated reasons while they were asymptomatic. Proviral sequences were detected at a high copy number in lymphoid tissue of both presymptomatic patients and patients with...

Topics

Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Base Sequence
DNA Primers
Genes, pol
Genetic Variation
HIV Envelope Protein gp120
HIV Infections
HIV-1
Humans
Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Phylogeny

Proviruses

Sequence Alignment

Sequence Homology, Amino Acid

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 7545945
DOI: 10.1128/JVI.68.9.5991-6005.1994
PMCID: PMC237004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7545945-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo distribution and cytopathology of variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop.PMID 7545945Read ↗

Progression to AIDS in macaques is associated with changes in the replication, tropism, and cytopathic properties of the simian immunodeficiency virus variant population.Semantic proximity Read ↗

Genetically and epidemiologically related "non-syncytium-inducing" isolates of HIV-1 display heterogeneous growth patterns in macrophages.Semantic proximity Read ↗

Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule.Semantic proximity Read ↗

Analysis of simian immunodeficiency virus sequence variation in tissues of rhesus macaques with simian AIDSSemantic proximity Read ↗

The cytopathicity of a simian immunodeficiency virus Mne variant is determined by mutations in Gag and Env.Semantic proximity Read ↗

Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages.Semantic proximity Read ↗

V3 loop sequence analysis of seven HIV type 1 group O isolates phenotyped in peripheral blood mononuclear cells and MT-2 cells.Semantic proximity Read ↗

Human immunodeficiency virus type 1 populations in blood and semen.Semantic proximity Read ↗

Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell-line and macrophage tropism of human immunodeficiency virus type 1.Semantic proximity Read ↗

Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse.Semantic proximity Read ↗

Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS.Semantic proximity Read ↗

Increased replication of non-syncytium-inducing HIV type 1 isolates in monocyte-derived macrophages is linked to advanced disease in infected children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.