Article
Trace amounts of sporadically reappearing HCV RNA can cause infection.
The Journal of clinical investigation - 1 Aug 2014
Veerapu Naga Suresh, Park Su-Hyung, Tully Damien C, Allen Todd M, Rehermann Barbara
Abstract excerpt
Successful hepatitis C virus (HCV) treatment is defined as the absence of viremia 6 months after therapy cessation. We previously reported that trace amounts of HCV RNA, below the sensitivity of the standard clinical assay, can reappear sporadically in treatment responders. Here, we assessed the infectivity of this RNA and infused 3 chimpanzees sequentially at 9-week intervals with plasma or PBMCs from patients...
Topics
- Animals
- Antiviral Agents
- Genetic Variation
- Hepacivirus
- Hepatitis C, Chronic
- Humans
- Interferon-alpha
- Liver
- Pan troglodytes
- Phylogeny
- Plasma
- RNA, Viral
- Ribavirin
- T-Lymphocytes
- Time Factors
- Transfusion Reaction
- Viremia