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<i>Podoplanin</i> Is a Novel Fos Target Gene in Skin Carcinogenesis

28 Aug 2008

Abstract excerpt

Expression and function of the oncogenic transcription factor activator protein (AP-1; mainly composed of Jun and Fos proteins) is required for neoplastic transformation of keratinocytes in vitro and tumor promotion as well as malignant progression in vivo. Here, we describe the identification of 372 differentially expressed genes comparing skin tumor samples of K5-SOS-F transgenic mice (Fos(f/f) SOS(+)) with...

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PMID: 18757399
DOI: 10.1158/0008-5472.can-08-0299

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