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Article

Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway.

Biochemical and biophysical research communications - 29 Nov 2002

Movsesyan Vilen A, Yakovlev Alexander G, Dabaghyan Elvira A, Stoica Bogdan A, Faden Alan I

Abstract excerpt

C(2)-ceramide, a cell-permeable analog of ceramide, caused cell death in cultured rat cortical neuronal cells. C(2)-ceramide-induced neuronal loss was accompanied by upregulation of caspase-3 activity, measured by cleavage of its fluorogenic substrate Ac-DEVD-AMC. Similar results were obtained when cortical neuronal cultures were treated with sphingomyelinase, an enzyme responsible for ceramide formation in the...

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PMID: 12437970
DOI: 10.1016/s0006-291x(02)02593-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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