Article
A mutation in the alpha 3 domain of Db that abrogates CD8 binding does not affect presentation of an immunodominant H-Y peptide.
Immunology - 1 May 1995
Dutz J P, Teh S J, Killeen N, Teh H S
Abstract excerpt
The peptidic nature of the male (H-Y) antigen, a model minor histocompatibility antigen in H-2b mice, has recently been demonstrated. In this study we show that the H-Y peptide, which is recognized by PM-1, a Db-restricted cytotoxic T-lymphocyte (CTL) clone, is absent in male H-2d spleen cells but present in male H-2d spleen cells that also express a transgenic Db molecule under its endogenous promoter. This...
Topics
- Animals
- Antigen Presentation
- CD8 Antigens
- Cell Line
- Culture Techniques
- Epitopes
- Female
- H-Y Antigen
- Immunodominant Epitopes
- Male
- Mice
- Mice, Inbred Strains