Article
Targeted expression of SV40 T antigen in the hair follicle of transgenic mice produces an aberrant hair phenotype.
Journal of cell science - 1 Mar 1995
Keough R, Powell B, Rogers G
Abstract excerpt
Directed expression of SV40 large T antigen (TAg) in transgenic mice can induce tissue-specific tumorigenesis and useful cell lines exhibiting differentiated characteristics can be established from resultant tumor cells. In an attempt to produce an immortalised mouse hair follicle cortical cell l...
Topics
- Animals
- Antigens, Viral, Tumor
- Cell Differentiation
- Cell Division
- Cell Line
- Gene Expression
- Gene Targeting
- Hair
- Keratins
- Mice
- Mice, Transgenic
- Microscopy, Electron
- Phenotype
- Sheep
- Simian virus 40