Article
High efficiency genetic modification of hair follicles and growing hair shafts.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2002
Saito Norimitsu, Zhao Ming, Li Lingna, Baranov Eugene, Yang Meng, Ohta Yukinori, Katsuoka Kensei, Penman Sheldon, Hoffman Robert M
Abstract excerpt
A technique for genetic modification of hair follicles was developed which results in efficient alteration of the hair shaft phenotype. High-level in vivo transgene expression was maintained in hair follicles such that growing hair shafts were phenotypically altered. Mouse anagen skin fragments, maintained in histoculture, were genetically modified at high efficiency with adenoviral-GFP. The histocultured skin...
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