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Article

Cyclic hair-loss and regrowth in transgenic mice overexpressing an intermediate filament gene.

The EMBO journal - 1 May 1990

Powell B C, Rogers G E

Abstract excerpt

We have produced transgenic mice containing up to 250 copies of a sheep wool intermediate filament keratin gene to study the effect of its expression on hair structure and development. Several transgenic lines expressed the gene and in the one containing 250 transgenes, a pattern of hair-loss and regrowth was stably established. Successive waves of hair growth follow periods of denuding like the natural...

Topics

Amino Acids
Animals
Hair
Intermediate Filament Proteins
Keratins
Mice
Mice, Transgenic
Microscopy, Electron
Mutation
Nucleic Acid Hybridization
RNA Probes
Restriction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sheep

Wool

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Identifiers

PMID: 1691707
DOI: 10.1002/j.1460-2075.1990.tb08266.x
PMCID: PMC551839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1691707-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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