Article
In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild-type p53.
European journal of immunology - 1 Sept 1993
Houbiers J G, Nijman H W, van der Burg S H, Drijfhout J W, Kenemans P, van de Velde C J, Brand A, Momburg F, Kast W M, Melief C J
Abstract excerpt
The central role of the p53 tumor suppressor gene product in oncogenesis is gradually being clarified. Point mutations in the p53 tumor suppressor gene are common in most human cancers and are often associated with p53 protein overexpression. Overexpressed wild-type or mutant determinants of the...
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