Article
CD8+ T cell recognition of polymorphic wild-type sequence p53(65-73) peptides in squamous cell carcinoma of the head and neck.
Cancer immunology, immunotherapy : CII - 1 Oct 2010
Andrade Filho Pedro A, Ito Daisuke, Deleo Albert B, Ferris Robert L
Abstract excerpt
The TP53 tumor suppressor gene contains a well-studied polymorphism that encodes either proline (P) or arginine (R) at codon 72, and over half of the world's population is homozygous for R at this codon. The wild-type sequence (wt) p53 peptide, p53(65-73), has been identified as a CD8+ T cell-defined tumor antigen for use in broadly applicable cancer vaccines. However, depending on the TP53 codon 72 polymorphism...
Topics
- CD8-Positive T-Lymphocytes
- Carcinoma, Squamous Cell
- Cell Line, Tumor
- Dendritic Cells
- Genotype
- Head and Neck Neoplasms
- Humans
- Peptides
- Polymorphism, Genetic
- Tumor Suppressor Protein p53